In order to produce a fermentation production of Ganoderma lucidum with skin care benefits,a liquid fermentation process of G. lucidum mycelium was designed by simulating the wild habitat stress of G. lucidum.The fermentation process was divided into two stages,the front stage provided suitable culture conditions for the growth of mycelium,to increase the mycelial biomass.In the latter segment,the stress factors simulating wild habitat were imposed to G. lucidum mycelium,to promote the production of polysaccharides and triterpenoids.The productions of G. lucidum polysaccharides and triterpenoids,the superoxide anion radical scavenging rate and the glycation inhibition rate were investigated,so as to screen the stress factors.It was found that three stress factors，which were Lactobacillus plantarum,chitinase and increasing temperature，had significant effects on increasing the active ingredient content in G. lucidum fermentation products.The crude polysaccharide and triterpenoid contents of G. lucidum fermentation product prepared by combining these three stress factors were 8.16 mg/g and 2.95 mg/g,respectively,and the superoxide anion radical scavenging rate and glycation inhibition rate of its 5% dilution solution were 81.56% and 56.11%,respectively.The skin-occlusive patch test proved that the G. lucidum fermentation product had no adverse reaction to human skin.The skin efficacy test proved that the G. lucidum fermentation product had anti-aging effect on human skin,which is manifested in brightening skin tone,removing yellowing and firming skin.