天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (3): 385-388.doi: 10.16333/j.1001-6880.2020.3.005

• 研究论文 • 上一篇    下一篇

党参药材活性成分党参炔苷的化学稳定性研究

廖江敏1,李林玉1,瞿云安2,杨雪峰1,杨军宣1*   

  1. 1重庆医科大学中医药学院,重庆 400016;2成都晶富医药科技有限公司,成都 610041
  • 出版日期:2020-03-28 发布日期:2020-05-12
  • 基金资助:

    国家药典委员会项目(ZG2016-2-06);重庆市卫生和计划生育委员会中医药科技项目(ZY201702132)

Study on the stability of lobetyolin in Codonopsis pilosula

LIAO Jiang-min1,LI Lin-yu1,QU Yun-an2,YANG Xue-feng1,YANG Jun-xuan1*   

  1. 1TCM School of Chongqing Medical University,Chongqing 400016,China;2Chengdu Jingfu Pharmaceutical Technology Co.,Ltd.,Chengdu 610041,China
  • Online:2020-03-28 Published:2020-05-12

摘要: 应用HPLC方法测定党参炔苷单体及党参药材提取液经不同条件(温度、受热时间、光照、pH等)处理后党参炔苷的含量变化,考察各种因素对其主要活性成分化学稳定性的影响。结果党参炔苷单体在60 ℃以下稳定性良好,在60 ℃以上其含量随温度的升高及受热时间的延长而显著降低(P<0.05);对光照敏感,80 Klx光照72 h后含量明显降低(P<0.05);在实验设计的不同酸碱度溶液中的稳定性良好,但pH>12时,含量逐渐降低。结果表明,党参炔苷对温度及光照敏感,且在党参药材提取液中的稳定性较单一成分(单体)更好。在药材加工处理、饮片炮制及中成药生产等过程中应注意控制温度、光照及处理时间。

关键词: 党参, 党参炔苷, 稳定性, 高效液相色谱法

Abstract: HPLC method was used to monitor the content changes of lobetyolin after being treated with different conditions(temperature,heating time,light,pH,etc.).Result showed the stability of lobetyolin was good under 60 ℃.When the temperature was over 60 ℃,the content of lobetyolin decreased significantly with the increase of temperature and the extension of heating time(P<0.05).After 72 hours of irradiation with 80 Klx,the content of lobetyolin decreased significantly(P<0.05),which would also decrease in the solution with pH>12.In conclusion,the stability of the pure product of lobetyolin was not as good as that in the extract of Codonopsis pilosula,temperature and light had significant effects on the stability of lobetyolin.

Key words: Codonopsis pilosula, lobetyolin, stability, HPLC

中图分类号: 

R282.6