In this paper,based on response surface method to optimize the hot air drying process of cultivated Fritillria cirrhosa D.Don,moisture transition point by single factor experiment,on the basis of the response surface method is used to design optimization cultivated F. cirrhosa two-stage variable warm wind drying process,the use of HPLC to establish cultivated F. cirrhosa nucleoside compounds content determination method,a model was established to evaluate the quality of medicinal materials by taking the character score of medicinal materials,the normalized (OD value) of the contents of total alkaloids,total starch and total nucleosides as indicators.By comparing the external characters and internal quality of the medicinal materials of constant temperature drying and sectional hot air drying,the optimal sectional hot air drying process was verified.Finally,the best hot air drying process of cultivated F. cirrhosa was obtained:drying at 60 ℃ to 45% water content,taking out and placing for 12 h,drying at 50 ℃ to less than 15.0% water content.The experimental results showed that the process was reliable and stable.Under this condition,the appearance and internal quality of cultivated F. cirrhosa were better,which could be used in the actual production of cultivated F. cirrhosa.

"> cultivation of F. cirrhosa, segmented temperature change, hot air drying, response surface design, nucleoside, processing technology