Lung cancer is still an important factor in cancer death worldwide.Intestinal microflora has become a new hot spot in the treatment of lung cancer due to its important position in the entero-lung axis.Intestinal microflora can affect the occurrence and development of lung cancer through genotoxicity,immune response regulation and metabolic changes.Balanced intestinal microflora can play a synergistic role in the chemotherapy of lung cancer,and play a synergistic role in immunotherapy,positively affecting the efficacy and prognosis of lung cancer treatment,and is also a potential marker and target of lung cancer.At present,probiotics and fecal bacteria transplantation and other methods to promote the treatment of lung cancer by regulating intestinal flora are still in the preliminary exploration stage.Traditional Chinese medicine and modern medicine play a synergistic role in the treatment of lung cancer.Traditional Chinese medicine has the advantages of simplicity and low cost,and can regulate intestinal flora well while treating lung cancer.This article reviews the relationship between intestinal microflora and lung cancer,and the role of traditional Chinese medicine in regulating intestinal microflora based on the theory of entero-lung axis.