Effect of Osthole on Isolated Pulmonary Arteries

doi:10.16333/j.1001-6880.2015.06.008

Abstract

Abstract: To study the effect of osthole on isolated pulmonary arteries by using force-electricity transducers,pulmonary arteries isolated from human beings and healthy SD rats and mesenteric arteries from SD rats were cut into rings (about 3 mm in length) and observed the response of artery contraction to different doses of osthole. The results showed that osthole (10⁹-10⁵ mol/L) relaxed phenylephrine precontrated isolated pulmonary arteries of both human beings and rats in a dose-dependent manner,but not mesenteric arteries and normal pulmonary arteries.Therefore,osthole relaxed human and rat isolated pulmonary arteries in a dose-dependent manner and was tissue specific.

Key words: osthole, pulmonary arterial hypertension, pulmonary arterial rings

CLC Number:

HE Guan-hong,TENG Zhen-xia,YAO Li*. Effect of Osthole on Isolated Pulmonary Arteries[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(6): 986-989.

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Effect of Osthole on Isolated Pulmonary Arteries

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