NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (4): 591-596.doi: 10.16333/j.1001-6880.2018.4.010

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Chemical Constituents from Periplaneta americana and Their Effects on Wound Healing

YAN Yong-ming1,2, ZHU Hong-jie1, XIANG Bin1, QI Jing-jing1, WANG Xin-long1, GENG Fu-neng3, CHENG Yong-xian1,2*   

  1. 1State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201，China; 2School of Pharmaceutical Sciences,Health Science Center,Shenzhen University,Shenzhen 518060,China; 3Sichuan Key Laboratory of Medical
    American cockroach,Chengdu 610000,China
  • Online:2018-05-07 Published:2018-05-07

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Abstract: Seventeen compounds were isolated from Periplaneta americana.Their structures were identified as cyclo(L-Tyr-L-Tyr) (1),cyclo(L-Tyr-L-Pro) (2),cyclo(L-Val-L-Tyr) (3),cyclo(Gly-L-Phe) (4),cyclo(Gly-L-Trp) (5),cyclo(L-Trp-L-Ser) (6),cyclo(L-Trp-L-Asn) (7),ginsenine (8),6-hydroxycoumarin (9),6-hydroxy-3,4-dihydrochromen-2-one (10),1-(3-ethylphenyl)-1,2-ethanediol (11),1-(4-ethylphenyl)-1,2-ethanediol (12),(E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (13),2-(3,4-dihydroxyphenyl)-2-oxoethyl acetate (14),protocatechuic acid (15),methylparaben (16),and syringic acid (17),respectively,by spectroscopic methods.Compounds 1-14 were isolated from the title insect species for the first time.In addition,biological evaluation towards wound-healing activities was conducted.Compound 13 showed a strong activity of inhibiting NO production.

Key words: medicinal insect, Periplaneta americana, wound healing, cyclic dipeptides

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