NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (9): 1626-1629.doi: 10.16333/j.1001-6880.2015.09.021

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Dissolution of Ultrafine EVO-F68 Solid Dispersion

YANG Hong-mei1, SHENG Rong2*, SONG Ying2, CAO Lei1, TANG An-ling1   

  1. 1 College of Pharmacy,Chengdu University of TCM,Chengdu 610075,China;  2 Teaching Hospital of Chengdu University of Traditional Chinese Medicine (TCM), Chengdu 610072,China
  • Online:2015-09-25 Published:2015-09-28

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Abstract: The objective of this study was to investigate the effect of solid dispersion on dissolution and solubility of evodiamine.The solid dispersion was prepared by melting method and poloxamer188 (F68) acted as the carrier.The distribution condition were analyzed using X-ray diffraction and infrared spectrum.The dissolution of the solid dispersions was detected by HLPC.Similarity factor f2 was used to determine the effect of dissolution on different treatment methods.According to the result of these tests,the dissolution of ultrafine EVO-F68 solid dispersion was evaluated.The results showed that evodiamine solid dispersions technology can significantly increase the dissolution of EVO,which cannot affect the content and structure of EVO and even greatly improved the dissolution.The optimal ratio of EVO and F68 was 1:4. Preferable solid dispersion was time-saving,highly efficient and reliable.

Key words: evodiamine, F68, solid dispersion, dissolution

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