NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (11): 1887-1891.doi: 10.16333/j.1001-6880.2015.11.010

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Chemical Constituents from the Raw Material of Lianhua-Qinwen Capsule

LIU Jin-ping1,2, JIA Wei-na1,2, LI Dong1,2, WANG Chun-hua1,2*, LI Zheng1,2   

  1. 1 Tianjin Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2 Research and Development Center of Traditional Chinese  Medicine,Tianjin International Joint Academy of Biotechnology & Medicine,Tianjin 300457,China
  • Online:2015-11-30 Published:2015-12-02

Abstract: Seventeen compounds were isolated from the raw material of Lianhua-Qinwen capsule by column chromatographies of silica gel,Sephadex LH-20 and preparative HPLC,which were elucidated by means of IR,MS, 1H NMR and 13C NMR.They were identified as (+)-pinoresinol (1), phillyrin (2), epipinoresinol4′-O-β-D-glucoside (3),matairesinol-4′-O-β-D-glucoside (4),chrysophanol-1-O-β-D-glucoside (5),aloe emodin-8-O-β-D-glucoside (6),chrysophanol (7), emodin (8), physcion (9), aloe-emodin (10), aloe-emodin acetate (11),quercetin-3-O-α-L-rhamnoside (12),kaempferol-3-O-α-L-rhamnoside (13),adoxosidic acid (14),gallic acid (15),benzoic acid (16),and β-sitosterol (17).This was the first time to investigate the chemical basis of raw material of Lianhua-Qinwen capsule through systematical isolation and identification methods,as a result,17 compounds were isolated and elucidated from it,which provided a strong research data for the chemical basis of Lianhua-Qinwen capsule.

Key words: Lianhua-Qinwen capsule, chemical constituents, lignan, anthraquinone

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