NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (11): 1824-1830.doi: 10.16333/j.1001-6880.2017.11.003

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Preparation and Evaluation of Quality and Security of Gentiopicroside Nanoemulsion

XIA Peng-fei1,2,3, MA Xiao4, WU Guo-tai1,5, LI Yang1,2,3, FAN Qin1,2,3, ZHAO Lei1,2,3*   

  1. 1Gansu University of Chinese Medicine; 2 Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province; 3 Gansu province Engineering Laboratory for TCM standardization technology and popularization, Gansu University of Chinese medicine; 4Second People’s Hospital of Gansu Province; 5Key Laboratory of Pharmacology and Toxicology of TCM of Gansu Province, Lanzhou 730000, China
  • Online:2017-11-29 Published:2017-11-30

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Abstract: The aim of this study was to optimize prescription of gentiopicroside nanoemulsion and evaluate its quality and security.Single-factor test and pseudo-ternary phase diagram were adopted to optimize prescription,optimal prescription was gentiopicroside/ethyl acetate/EL-35/absolute ethyl alcohol/Ultrapure water (1.77∶7.66∶5.94∶11.91∶72.71),the particle size of nanoemulsion was 23.08 nm;The content of gentiopicroside was determined by HPLC;Stability of prepared gentiopicroside nanoemulsion was good in the state of different temperatures,illumination intensity and humidity conditions;The security test demonstrated that there was no acute toxicity;The optimized preparation technology of gentiopicroside nanoemulsion was simple,repeatable and stable.It provided the possibility to improve the bioavailability and clinical application.

Key words: gentiopicroside, nanoemulsion, preparation technology, quality evaluation

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