Abstract: The study was focus on the flavonoids of Blumea balsamifera DC.and their bioactivities.The compounds of B.balsamifera were isolated and purified with various chromatographic techniques,nine flavonoids were isolated from the leaves of B.balsamifera,their structures were identified as dihydroquercetin-4′-methyl ether (1),tamarixetin (2),3,3′-di-O-methylquercetin (3),dihydroquercetin-7,4′-dimethyl ether (4),(2α,3β)-dihydrorhamnetin (5),blumeatin (6),sterubin (7),enodicytol (8),dihydroquercetin (9),respectively.Compounds 3,5 and 8 were isolated from this plant for the first time.DPPH radical scavenging method was used to evaluate antioxidant activity,and PNPG method was used to determine α-glucosidase inhibitory activity of these compounds.The results indicated that compound 2 and 5-9 showed strong antioxidant activities;and compounds 1-3,5 and 9 displayed stronger inhibitory activities than the positive control of acarbose.The results provided a theoretical basis for the quality evaluation and deep development and utilization of B.balsamifera.

Key words: Blumea balsamifera DC., flavonoids, antioxidant activity, α-glucosidase inhibitory activity