Abstract: To investigate the hypoglycemic effects of ethanol extract and its mechanism from Stenoloma chusanum (L) Ching on type 1 diabetic rats.The research group established a model of type 1 diabetes rats by intraperitoneal injection of streptozotocin (STZ).The SD rats were randomly divided into four groups,including control group,model group,low dose group of 30 mg/kg (LG) and high dose group of 60 mg/kg (HG) and diabetic rat’s model induced by STZ.Rats in LG and HG was oral administration by ethanol extract from SLC once a day until 28 days and gastric perfusion volume is 20 mL/kg.The body weight,fasting blood glucose (FBG),serum insulin(INS),glucokinase (GCK) and aldose reductase (AR) of rats in each group were measured and the morphology of pancreas was observed The 28 days igadministration of extract of SLC decreased the negative growth of body weight,FBG and AR significantly in diabetic rats induced by STZ (P<0.05) and increased IINS,GCK(P<0.05).Morphological observations show that the number of islets in LG and HG was more than that in model group.Islet and exocrine atrophy were reduced in varying degrees.Ethanol extract from SLC has the hypoglycemic effect on fasting blood glucose in diabetic rats induced by STZ,and the mechanism may be related to decreasing aldose reductase,increasing serum glucokinase,protecting the islets and promoting insulin secretion by pancreatic β cells.

Key words: Stenoloma chusanum (L) Ching, type 1 diabetes, hypoglycemia