Isolation and Identification of Anti-Mycobacterium tuberculosis Components from Leonurus artemisia (Laur.) S.Y.Hu F

doi:10.16333/j.1001-6880.2018.12.018

Abstract

Abstract: Tuberculosis is classified as pulmonary tuberculosis and extrapulmonary tuberculosis.The endometrial tuberculosis belongs to extrapulmonary tuberculosis,which is the main cause of infertility.Leonurus artemisia (Laur.) S.Y.Hu F is a traditional Chinese medicine,commonly used in the treatment of gynecologic diseases.In screening,it was found that the ethanol extract of Leonurus artemisia (Laur.) S.Y.Hu F had anti-Mycobacterium tuberculosis activity.Based on bioassay-guided isolation,compound 1 with the activity of inhibiting Mycobacterium tuberculosis was separated from the ethyl acetate extracts of Leonurus artemisia (Laur.) S.Y.Hu F.It was identified as leonurine,and with MIC value of 80μg/mL for against tubercle bacillus.This discovery might provide a new clue for the treatment of uterine tuberculosis.

Key words: Leonurus artemisia (Laur.) S.Y.Hu F, leonurine, mycobacterium tuberculosis, active component

CLC Number:

R284.1
R93

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Isolation and Identification of Anti-Mycobacterium tuberculosis Components from Leonurus artemisia (Laur.) S.Y.Hu F

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