Cornus officinalis is an important resource of Traditional Chinese Medicine (TCM).The development and utilization of TCM has occupied an important position in the research field of natural products.And the chemical constituents from C. officinalis mainly include iridoids,tannins,flavonoids,triterpenes,aromatic,phenolic acids,and essential oils.Meanwhile,C. officinalis had a wide range of wide pharmacological activities,such as hepatic and renal protection,antidiabetes,antioxidation,antitumor activity,and hair growth regulation.In addition,the formulas containing C. officinalis are clinically used for tonic and astringent medicine.The analytical methods of quality control about C. officinalis mainly include high performance liquid chromatography (HPLC),liquid chromatography-mass spectrometry (LC-MS),gas chromatography-mass spectrometry (GC-MS),and inductively coupled plasma mass spectrometry (ICP-MS).This review summarizes the chemical constituents,pharmacology,formula applications and quality control of C. officinalis in the recent 40-year literatures in order to promote the further rational development and utilization of the C. officinalis.