NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2023, Vol. 35 ›› Issue (2): 231-235.doi: 10.16333/j.1001-6880.2023.2.006

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Alkaloids from leaves of Piper sarmentosum

SHAO Jin-hua1,2,LIU Yi-lin1,LYU Jing-kun3,CHEN Xiao-ming1,2,3*   

  1. 1School of Chemistry and Bioengineering,Hunan University of Science and Engineering;2Hunan Provincial Engineering Research Center for Ginkgo Folium,Hunan University of Science and Engineering;3Hunan Hengwei Pharmaceutical Co.,Ltd.,Yongzhou 425100,China
  • Online:2023-02-28 Published:2023-03-02


The chemical composition of Piper sarmentosum leaves and their antibacterial activity against Staphylococcus aureus were investigated. Seven alkaloid components were isolated and purified from the total alkaloid parts of P. sarmentosum leaves by repeated column chromatography such as silica gel,Sephadex LH-20 and semi-preparative HPLC.According to the spectroscopic data,combined with the physical and chemical properties,their structures were identified as chaplupyrrolidone C (1),chaplupyrrolidone A (2),chaplupyrrolidone B (3),sarmentamide A (4),N-(3-phenylpropanoyl) pyrrole (5),3-(4-hydroxy-3,5-dimethoxyphenyl) propanoylpyrrole (6),3-(3,4,5-trimethoxyphenyl) propanoylpyrrole (7).Accordingly,compound 1 is discovered to be a new amide alkaloid and compound 7 was isolated for the first time from P. sarmentosum.The microbial inhibition activity of all the isolated compounds was tested by the broth microdilution method,and the results showed that compounds 1-4 exhibited different degrees of inhibition against Staphylococcus aureus.

Key words: Piper sarmentosum, amide alkaloids, chemical composition, Staphylococcus aureus

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