NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2023, Vol. 35 ›› Issue (9): 1554-1561.doi: 10.16333/j.1001-6880.2023.9.009

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Chemical constituents of Senecio scandens and their anti-tobacco mosaic virus activity

FU Tao1,LI Ya-li1,ZHANG Wei1,WU Jiang-mei1,LIU Yang1,LUO Xin-xiang1,YAN Xiao-hui1*,HU Shi-jun2*   

  1. 1Key Laboratory of Forest Disaster Warning and Control in Yunnan Province,College of Biodiversity Conservation,Southwest Forestry University;2College of Forestry,Southwest Forestry University,Kunming 650233,China
  • Online:2023-09-22 Published:2023-09-21


In order to provide a theoretical basis for the development of new plant virus inhibitors,the chemical components of Senecio scandens and its activity against tobacco mosaic virus (TMV) were determined.The chemical constituents of the ethyl acetate extract from the aboveground part of S. scandens were separated by silica gel,Sephadex LH-20,MCI and other column chromatography methods,and its structures were identified by NMR and MS data.The inhibitory activity of the compound against TMV was screened by the half-leaf spot method in vivo.Thirteen compounds were isolated from the ethyl acetate extract of S. scandens. According to their physicochemical properties and spectral data,they were identified as 9,19-cyclolanost-24-en-3-one (1),7β-methoxystigmast-5-en-3β-ol (2),dotriacontane (3),ursolic acid (4),stigmasterol (5),(22E)-ergosta-6,22-diene-3β,5β,8α-triol (6),kaempferol (7),indole-3-carboxaldehyde (8),nepetin (9),quetrcetin (10),taxifolin (11),jacaranone (12),phytol (13).Except compound 7 and compound 10,the other compounds were isolated from this plant for the first time.The results showed that compound 8 and compound 13 had strong anti-TMV activity.

Key words: Senecio scandens, chemical constituents, anti-TMV activity, half-leaf method

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