Abstract: The chemical constituents of Nothapodytes nimmoniana distributed in Mengla,Yunnan,China were isolated by column chromatography on silica gel,MCI and Sephadex LH-20 and identified by chemical and spectral analyses.Nineteen compounds were finally isolated and purified from twigs of N. nimmoniana. Their structures were elucidated as β-amyrin(1),7-keto-β-sitosterol (2),stigmasterol(3),stigmast-5-en-3β,7β-diol(4),propyloxyamyrin(5),liriodendrin(6),coniferin(7),glucosyringic acid(8),syringin(9),caffeic acid(10),6,7-dihydroxycoumarin(11), (3R)methyl-3,6,7-trimethylnonadecanoate(12),camptothecine(13),9-methoxycamptothecine(14),10-hydroxycamptothecine (15),tricin(16),stigmast-5-en-3β,7α-diol(17),daucosterol(18),sitosterol(19).Compounds 1-12 were obtained from this plant for the first time.

Key words: Nothapodytes nimmoniana, twigs, chemical constituents, camptothecins