Abstract: The objective of this study was to discuss the effects of WuFu Xinnaoqing (WFXNQ) on blood liqid,oxygen free radical and histomorphology in rat model with experimental early atherosclerosis.The rat model was induced by feeding lipid emulsion.The experimental rats were then gavaged with low,medium and high doses of WFXNQ (0.31,0.62 and 1.24 g/kg) and fenofibrate (20 mg/kg) for 10 weeks followed by the detection of the total cholesterol (TC),triglycerides (TG),high density lipoprotein cholesferol (HDL-C),low density lipoprotein cholestorol (LDL-C),MDA,superoxide dismutase (SOD) activity in rats’ serum of each groups.In addition,the tissue slices and super thin slices of rat carotid artery were prepared and observed under light microscopy and electron microscopy for pathological changes.The results showed that compared with model group,the serum TC,TG and MDA Levels of WFXNQ treatment groups were significantly reduced (P<0.01).The HDL-C level,SOD activity of sample groups were significantly higher that these of the model group (P<0.05,0.01).The light microscopic and electron microscopic observation results showed that the injury of rat tissues in WFXNQ treatment groups were significantly reduced compared with that of control group,in which the medium dosage of WFXNQ treatment group (0.62 g/kg) showed the most significant change.Based on the above results,it was concluded that WFXNQ had preventive and treatment effects on experimental early atherosclerosis by regulating blood fat,lowering fat deposition on artery walls,scavenging oxygen free radicals and inhibiting the generation of lipid peroxidation products.

Key words: WuFu Xinnaoqing, atherosclerosis, lipid peroxidation, blood fat