Abstract: To study the function of improving human skin moisture after oral hyaluronic acid marine oligopeptide powder.110 cases of applicable were selected as the study subjects.Their functional and safety indicators were measured after oral the powder for 30 days.Compare changes of the indicators before and after the experiment between normal control groups(NCG) and trail groups(TG).The results showed that there are significant differences of improving skin moisture compared with those of the initial TG and NCG（P＜0.01）.The safety indicators of the subjects had no abnormal change.Hyaluronic acid marine oligopeptide powder can significantly improve the skin moisture,and be harmless to human health.

Key words: hyaluronic acid marine oligopeptide powder, skin moisture, human trials