NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (Suppl): 84-86. doi: 10.16333/j.1001-6880.2015.S.021

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Separation,Purification and Determination of Anti-cancer Drugs Varubicin

ZHANG Chang-xiang*   

  1. China Bluestar Chengrand Chemical Industry Research & Design Institue Co.Ltd.,Chengdu 610041,China
  • Online:2015-12-01 Published:2016-01-12

Abstract: Preparative chromatography purification of valrubicin from crude synthetic drug has been uccessfully performed in this study.The method of precipitation with bad solvent was used to remove impurity firstly.Then a tandem column chromatography were applied for purifying valrubicin.After this process,the purity of valrubicin achieve 98.9%.In addition,corresponding HPLC method was established for determinating valrubicin.

Key words: Valrubicin, separation and purification, HPLC

CLC Number: