Ginseng is one of the important herbs,belonging to Araliaceae species,which mainly contain ginsenoside.Thousands of papers have reported its biological activities.Most of them showed neuroprotective effects,anti-tumor,anti-virus,liver-protection,hypoglycemia,immune regulation and so on.Recently,a series of rare induced ginsenoside changed in side chain were reported.There rare ginsenosides with higher pharmaceutical activity.However,the low concentration or absence of these rare ginsenosides from natural sources significantly hinders the exploration of their pharmaceutical activities and further clinical application.Therefore different means of transformation to obtain rare ginsenosides will provide the basis for the follow-up research.