The effect of different processing methods on the chemical components of Leonuri Herba and the action of Leonuri Herba on promoting blood circulation and removing blood stasis was studied to provide guidance for rational use of drugs.The leonurine hydrochloride,stachydrine hydrochloride,rutin,hyperin and isoquercitrin were chose as the index to evaluate the effect of different processing methods on the alkaloid components and flavonoid components in Leonuri Herba.The thrombin time,fibrinogen,whole blood high shear viscosity,whole blood mid shear viscosity,whole blood low shear viscosity,whole blood high shear reduced viscosity,whole blood mid shear reduced viscosity,whole blood low shear reduced viscosity and plasma viscosity were chose as the index to evaluate the effect of different processing methods on the action of Leonuri Herba on promoting blood circulation and removing blood stasis based on acute blood stasis model rats.The results show that the contents of alkaloid components such as Leonurine hydrochloride and Stachydrine hydrochloride in Leonuri Herba were decreased slightly compared with before processing,and the flavonoid components such as Rutin,Hyperin and Isoquercitrin were decreased significantly.Leonuri Herba processed with different methods could differently improve the hemorheology index of acute blood stasis model rats.This study showed that different processing methods had a little effect on the alkaloid components of Leonuri Herba,but had great effect on the flavonoid components.Different processing methods could differently improve the action of Leonuri Herba on promoting blood circulation and removing blood stasis.