关键词: 木犀草素, 氨基, 醌, 合成, 抗氧化性, 水溶性

Abstract: In order to enhance the pharmacologically activity of luteolin,the active group with amino is introduced into the 6' position of molecular structure of luteolin.Firstly,it will play a role in enhancing efficacy.Secondly,the entire molecule can be adjusted for the lipid/water distribution coefficient.Hence the pharmacokinetic parameters of the lead compound are affected.Therefore the pharmacological testing of anti-inflammatory activity can be conducted.Luteolin as the raw material,reacted with fatty amine,alcohol amine,benzylamine by continuous reaction of air oxidation and Michael addition at a specific acidity.Relatively stable aminoquinone compounds based on luteolin structure were synthesized.This method had the characteristics of fewer steps,mild reaction conditions and environmentally friendly.The targeted compounds were structurally characterized by IR,UV,NMR and MS.The antioxidant properties and water solubility of the products were studied preliminarily.

Key words: luteolin, amino; quinone, synthesis, antioxidant properties, water solubility