关键词: 阿魏酸, APP/PS1转基因小鼠, 凋亡, 氧化应激

Abstract: In this study,the effects of ferulic acid on oxidative stress and apoptosis related proteins in the APP/PS1 transgenic mice brain were investigated. Western blot and Real-Time PCR methods were used to detect the expression of apoptosis related proteins in brains of the WT mice,APP/PS1 transgenic mice and different concentrations of ferulic acid treatment mice,and SOD activity and MDA content were detected in mice brain of each group. The activity of SOD increased compared to the AD model mice,and the content of MDA reduced after ferulic acid treatment,the concentration of ferulic acid in treatment group was the most obvious;The expression of p-JNK,p-C-Jun,Caspase-3,Bax and Bcl-2 was increased compared to those of the WT mice,the hyperphosphorylation proteins were significantly reduced after ferulic acid treatment,the concentration of ferulic acid in treatment group was the most obvious. These results indicated that ferulic acid can decrease oxidative stress effect in AD mice brain through its powerful antioxidant activity,and decline the level of apoptosis related proteins in AD mice brain. These results prompted that ferulic acid had important theoretical significance in the clinical treatment of AD.

Key words: ferulic acid, APP/PS1 transgenic mice, apoptosis, oxidative stress