关键词: 槲皮素, 紫杉醇, 神经病理学疼痛, 大鼠, Wnt信号通路

Abstract: This study investigated the effect of quercetin on paclitaxel-induced neuropathic pain in rats.A model of neuralgia was induced by intraperitoneal injection of 4 mg/kg paclitaxel for 30 weeks,and 30,50 and 100 mg/kg quercetin was administered continuously.After 7 days of gavage treatment,the mechanical abnormal pain was evaluated by Von Frey test,and the migration effect of macrophages on rat dorsal root ganglion (DRG) was detected.The DRG cells were incubated with paclitaxel and quercetin to observe the nerve.The growth of the neurites was evaluated by Western blotting.The results showed that quercetin could significantly increase the shrinkage threshold of rats with neuralgia in a dose-dependent manner,and reduce the migration of macrophages.Increased levels of inflammatory cytokines TNF-α and IL-1β in rat spinal cord induced by paclitaxel,and a dose-dependent manner to inhibit paclitaxel-induced neuronal neurite outgrowth and key molecules of Wnt signaling pathway in rat dorsal ganglion neurons The levels of Wnt3α and β-catenin proteins suggest that quercetin may affect the level of inflammatory factors in the spinal cord and reduce inflammation by regulating the Wnt/β-catenin signaling pathway.Taxol induced cell migration neuropathology of pain in rats exert improvement effects.

Key words: quercetin, paclitaxel, neuropathological pain, rat, Wnt signaling pathway