天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (6): 1064-1081.doi: 10.16333/j.1001-6880.2024.6.017

• 综述 • 上一篇    下一篇

鬼箭羽化学成分和药理作用的研究进展及其质量标志物预测

杜雨璇1,2，谢治深1，徐江雁1*，王   潘1*   

  1. 1河南中医药大学 中医药科学院；2河南中医药大学 药学院，郑州 450046
  • 出版日期:2024-06-26 发布日期:2024-06-26
  • 基金资助:
    国家重点研发计划（2020YFE0201800）；河南省高校科技创新人才项目（23HASTIT044）；河南省科技攻关项目（232102310447）；河南省高校科技创新团队项目（21IRTSTHN026）

Research progress on chemical compounds and pharmacological effects of Euonymus alatus (Thunb.) Siebold and predictive analysis on quality markers

DU Yu-xuan1,2,XIE Zhi-shen1,XU Jiang-yan1*,WANG Pan1*   

  1. 1Academy of Chinese Medical Sciences,Henan University of Chinese Medicine;2College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China
  • Online:2024-06-26 Published:2024-06-26

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摘要： 鬼箭羽始载于《神农本草经》，列为中品，具有通经、破血、杀虫和散瘀止痛等功效。现代药理学研究表明其具有降血糖、抗肿瘤、抗炎镇痛、抗菌、抗氧化、抗病毒等药理作用，其活性成分以黄酮类和萜类成分为主。本文通过对鬼箭羽的化学成分、药理作用、毒理等方面进行综述，并基于此，从植物亲缘关系、化学成分有效性、化学成分可测性等方面对鬼箭羽的质量标志物进行推测分析，初步预测芦丁、槲皮素、香橙素、儿茶素、β-谷甾醇、鬼箭羽二萜A和11-羰基-β-乳香酸等成分可作为鬼箭羽潜在的质量标志物，以期为鬼箭羽的质量控制和临床用药规范提供科学依据。

关键词: 鬼箭羽, 质量标志物, 黄酮类, 三萜类, 糖尿病肾病, 抗肿瘤

Abstract:

Euonymus alatus (Thunb.) Siebold is considered as the wing-like appendage or wing-like branch,which was first recorded in the Shennong′s Herbal Classic,is classified as a middle-grade herb with the effects of promoting blood circulation,dispelling blood stasis,killing parasites,and relieving pain.Modern pharmacological studies have shown that it has pharmacological effects such as lowering blood glucose,anti-tumor,anti-inflammatory,analgesic,antibacterial,antioxidant,and antiviral effects,and its active ingredients are rich,and most of the current studies are focused on the flavonoid and terpenoid compounds.This article provides a comprehensive review of the chemical composition,pharmacological effects,toxicity,and other aspects of E. alatus.Based on the plant′s phylogenetic relationship,the effectiveness of its chemical components,and the detectability of its chemical composition,speculations and analyses are made on the potential quality markers (Q-Marker) of E. alatus.It is preliminarily predicted that components such as rutin,quercetin,hesperidin,catechins,β-sitosterol,euonymuditerpene A,11-keto-β-boswellic acid,etc.can be potential quality markers of E. alatus.This review aims to provide scientific evidence for the quality control and standardized clinical use of E. alatus.

Key words: Euonymus alatus, quality marker, flavonoids, triterpenoids, diabetic kidney disease, anti-tumor effects

中图分类号:  R962

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