关键词: 槲皮素, 高脂日粮, 氧化应激, 抗氧化能力, 血脂代谢

Abstract: This study aimed to investigate the effects of quercetin on scavenging free radicals and serum lipid metabolism of mice fed with high-fat diet. The scavenging activities of quercetin on DPPH•, •OH and ABTS+• radicals were evaluated in vitro, respectively. Thirty-two male Kunming mice (weight: 20±2 g) were randomly divided into 4 groups. They were fed with ordinary diet, high-fat diet, high-fat diet plus 0.05 g/kg quercetin and high-fat diet plus 0.1g/kg quercetin, respectively. After 9 weeks, the level of reactive oxygen species (ROS) in liver, contents of malondialdehyde (MDA) and antioxidant enzymes activities in liver and serum lipid level were determined. The results showed that quercetin had strong scavenging efficiencies on DPPH•, •OH and ABTS+• radicals. Moreover, the scavenging capability strengthened with its increasing dosages, although this enhancing trend gradually weakened. 0.05 g/kg quercetin could remarkably decrease the level of ROS in liver and the content of MDA, enhance the antioxidant capacity of mice, as well as improve the level of serum lipid while 0.1 g/kg quercetin had no significant effects. The results indicated that 0.05 g/kg quercetin could effectively enhance antioxidant capacity, relieve oxidative stress caused by high-fat diet and improve serum lipid metabolism.

Key words: quercetin, high-fat diet, oxidative stress, antioxidant capacity, serum lipid metabolism