关键词: 拟缺香茶菜水提物, 艾氏腹水癌, 肉瘤180, 肝癌, lewis肺癌

Abstract: To study the effects of Rabdosia excisoides water extract on transplanted tumors and the immunological influence in mice.The antitumor effects of Rabdosia excisoides water extract in 5g/kg dosage on Ehrlich ascites carcinoma(EAC),Sarcoma 180(S₁₈₀),hepatoma carcinoma (HCA),and Lewis lung carcinoma were investigated by using the inplanted tumor animal models.The immunological effects were observed by using hemolysin and delayed hypersensitive tests inmice.The 5-Fu was used as positive control and the normal saline as blank control.It showed that Rabdosia excisoides water extract had significant cytotoxicity against EAC cell in vitro,in addition to solid models S₁₈₀ (inhibition rate of 38.83%),hepatoma carcinoma (inhibition rate of 32.03%) and Lewis lung carcinoma (inhibition rate of 30.97%) had some effects in vivo, but on other tumor effect is not obvious,when compared with the control group,There was no prominent influence on immunological state of the animals.The experiment can show that Rabdosia excisoides water extract has a little antitumor effect on Ascites tumor and some antitumor effect on solid models tumors,there is no obvious influence on immunological state of the animals.

Key words: Rabdosia excisoides water extract, Ehrlich ascites carcinoma, Sarcoma 180, hepatoma carcinoma, lewis lung carcinoma