Abstract: To investigate the hypolipidemic effects of honeycomb extract in vivo, healthy male mice were fed with high-fat diet to create a hyperlipidemic animal model. According to the body weight,72 mice were randomly divided into 6 groups:blank control group (normal feed + normal saline),a high-fat control group (high-fat diet+ normal saline),a positive control group (high-fat diet+simvastatin solution),a high dose group (high-fat diet+1.0 g/mL honeycomb extract),a medium dose group (high-fat diet+0.5 g/mL honeycomb extract) and a low dose group (high-fat diet+ 0.25 g/mL honeycomb extract).This experiment conducted about 5 weeks and these mice were fed every day in the same time,took blood from eyes weekly.Serum total cholesterol (TC),triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were determined.The results showed body weight of each group had no significant difference (P>0.05).The levels of TC,TG and HDL-C of three dosage groups were significant lower than those of the high-fat control group (P<0.05).Among them,the high dosage group achieved best antihyperlipidemic effect,followed by the medium dosage group and low dosage group.In addition,the high dosage group and the positive control group had no significant difference (P>0.05). Hence,honeycomb extract had a good hypolipidemic effect and it can be used for the prevention and treatment of hyperlipidemia disease.

Key words: honeybee comb, mice, hypocholesterolaemic effect, total cholesterol, triglyceride, high density lipoprotein cholesterol