Isolation,Identification and Antimicrobial Activity of Secondary Metabolites from a Soil-derived Streptomyces from Arid Habitats of Qinghai

doi:10.16333/j.1001-6880.2015.11.012

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (11): 1900-1904.doi: 10.16333/j.1001-6880.2015.11.012

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Isolation,Identification and Antimicrobial Activity of Secondary Metabolites from a Soil-derived Streptomyces from Arid Habitats of Qinghai

YU Zhi-yin1,2, YU Ming-ming2, LUO Jian-ying2, SU Can2, XUE Quan-hong3, HUANG Sheng-xiong2, SUN Yun1*, MA Ya-tuan 2,3*

1 College of TCM,Xinjiang Medical University, Xinjiang Urumqi 830011,China; 2 State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Kunming 650201,China;3 College of Science, Northwest A&F University,Shaanxi Yangling 712100,China

Online:2015-11-30 Published:2015-12-02

Abstract

Abstract: Five compounds, N-acetyramine (1), N-acetyltryptamine (2),pyrrole-2-carboxamide (3),inthomycin C (4) and inthomycin B (5),were isolated from the fermentation broth of Streptomyces pactum KIB-HL8,and their structures were elucidated by analysis of NMR and MS data.In addition,compound 4 moderately inhibited growth of Staphylococcus aureus. Compounds 1 and 2 showed significant antifungal activity against Botrytis cinerea. Compound 3 displayed inhibitory activity against Alternaria solani.

Key words: Streptomyces, secondary metabolites, isolation and identification, antibacterial activity, antifungal activity

CLC Number:

YU Zhi-yin1,2, YU Ming-ming2, LUO Jian-ying2, SU Can2, XUE Quan-hong3, HUANG Sheng-xiong2, SUN Yun1*, MA Ya-tuan 2,3*. Isolation,Identification and Antimicrobial Activity of Secondary Metabolites from a Soil-derived Streptomyces from Arid Habitats of Qinghai[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(11): 1900-1904.

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Isolation,Identification and Antimicrobial Activity of Secondary Metabolites from a Soil-derived Streptomyces from Arid Habitats of Qinghai

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