Aspergillus versicolor is a common species of the Aspergillus genus,which widely distributed in marine,higher plants,mangroves,arthropods,and other habitats.Recent studies showed that A. versicolor could produce alkaloids,terpenoids,polyketides and other structurally diverse secondary metabolites that possessed antibacterial,anti-tumor,antioxidant,anti-virus,and other activities.This paper summarized the research progress on the structure and biological activity of secondary metabolites isolated from 37 strains of A. versicolor in 2017 to 2022,involving 325 secondary metabolites,111 of which were new compounds.This paper revealed that the secondary metabolites of A. versicolor had a close relationship with their habitats.It will shed some light on digging new natural products by using more strains of A. versicolor and other microorganisms from different habitats.