Abstract: Quinazoline is a class of important compounds containing pyrimidine heterocyclic,firstly isolated from fungi and bacteria.Quinazolinones have varieties of biological activities,such as anti-inflammatory,analgesic,antifungi,anti-convulsion,anti high blood pressure,and antitumor,etc. The quinazolinone analogs synthesis and in-depth biological activities studies have became one of the highlights in the organic chemistry.This paper summarized the researches progress on biological activities and structure-activity relationship of quinazolinone compounds.

Key words: quinazolinone, biological activities, chemical structural transformation, structure-activity relationship