NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (12): 2040-2045.doi: 10.16333/j.1001-6880.2015.12.008
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GUO Jian1, LI Ming-gang2, DONG Yuan1, XU Wei2, LI Yan1*
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Published:
Abstract: The secondary metabolites of a fungus isolated from tin mine tailings were separated by silica gel column,sephadex LH-20 gel column and HPLC.14 compounds were obtained.Their structures were identified by mass spectrometry and nuclear magnetic resonance analyses and elucidated as:Stachyflin (1),Brevicompanine E(2),Brevicompanine H (3),Brevicompanine D (4),(2S,3S)-3,5-dihydroxy-2-((Z)-4-(hydroxymethyl)-8- methylnona-3,7-dien-1-yl)-2-methyl-3,4,8,9-tetrahydropyrano[2,3-e]isoindol-7(2H)-one (Stachybotrin A) (5) 5-((1R,2R,5R,6R)-2,5-dihydroxy-7-oxabicyclo[4.1.0]heptan-2-yl)-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl)-4-hydroxypyridine-2(1H)-one(Apiosporamide) (6),(3s)-6,8- dihydroxy-3-methyl-3,4-dihydro-1H-isochromen-1one (7),Adenosine (8),4-hydroxybenzaldehyde (9),methyl (5-amino-2-hydroxyphenyl) acetate (10),Uridine (11),Acetylstachyflin (12),Nicotinamide (13),(S)-7-benzyl -6-methyl-6,7-dihydrobenzo[6,7][1,4]diazepino[2,1-b]quinazoline-5,13-dione(Benzomalvin A) (14).Compound 5 showed antitumor activity with ED50 values of 21.59,23.45 and 37.36 μg/mL against HT-29,A-549 and MCF-7,respectively.
Key words: fungus, fermentation, tin mine, secondary metabolites
CLC Number:
Q815
GUO Jian1, LI Ming-gang2, DONG Yuan1, XU Wei2, LI Yan1*. Secondary Metabolites of a Fungus Isolated from a Tin Mine Tailings[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(12): 2040-2045.
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URL: https://www.trcw.ac.cn/EN/10.16333/j.1001-6880.2015.12.008
https://www.trcw.ac.cn/EN/Y2015/V27/I12/2040