NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (Suppl): 6-9.doi: 10.16333/j.1001-6880.2015.S.002

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Chemical Constituents from Centipeda minima

ZHANG Yu-bo1, WU Peng2, WU Zhong-nan1, YANG Li1, WANG Guo-cai1*, LI Yao-lan1   

  1. 1 Institute of Traditional Chinese Medicine & Natural Products,College of Pharmacy,Guangdong Province Key Laboratory of Pharmaceutical Constituents of TCM and New Drugs Research, Jinan University,Guangzhou 510632,China;2 International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China
  • Online:2015-12-01 Published:2016-01-12

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Abstract: Eleven compounds were isolated from Centipeda minima and purified by repeated silica gel,Sephadex LH-20 column chromatography,and preparative HPLC.The structures were elucidated on the basis of their spectral characteristics and identified as brevifolin (1),4,5-β-dihydroxy-2-β-(isobutyryloxy)-10-β-H-guai-11(13)-en-12,8-β-olide (2),arnicolide C (3),microhelenin C (4),arnicolide B (5),ursolic acid (6),8-hydroxy-9,10-diisobutyryloxythymol (7),quercetin-3-methyl ether (8),quercetin3,3′-dimethyl ether (9),daucosterol (10),stigmasterol (11).Compounds 4 and 6 were isolated from this plant for the first time.

Key words: compositae, Centipeda minima, chemical constituents, structural identification

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