Effect of Allicin on TNF-α Expression in Mice with Alzheimer's Disease

doi:10.16333/j.1001-6880.2016.11.019

Abstract

Abstract: In this study,the effect of allicin on the expression of TNF-α in the brain of transgenic mice was investigated by immunofluorescence,Western blot and RealTime PCR assays.It was found that the expression of TNF-α in APP/PS1 transgenic mice increased compared with the wild-type mice.These results suggested that there were inflammation reaction in APP/PS1 transgenic mouse brain,but the expression of TNF-α in allicin treatment group was significantly lower than that in APP/PS1 transgenic mice.These results prompt that there were inflammation reaction in APP/PS1 transgenic mouse brain.TNFα expression in allicin treatment group was lower than that in APP/PS1 transgenic mice.

Key words: allicin, Alzheimer&rsquo, s disease, APP/PS1 transgenic mice, TNF-&alpha

CLC Number:

R941.02

ZHANG Hao1*,WANG Yue2,PAN Hai1. Effect of Allicin on TNF-α Expression in Mice with Alzheimer's Disease[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(11): 1793-1796.

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Effect of Allicin on TNF-α Expression in Mice with Alzheimer's Disease

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