Alzheimer′s disease (AD),a neurodegenerative disease with a significant increase in prevalence with age and mortality,has become the global public health and social problem.The pathogenesis of AD is complex,involving multiple pathological processes.Natural products which contain rich and diverse active ingredients,have become the source of anti-AD drug discovery and many of them have shown the potential for application.This review summarizes targets of anti-AD natural active ingredients discovered in recent years based on the hypothesis of AD pathogenesis,hoping to provide reference for the development of anti-AD drugs in future.