Inhibitory Effect of Low Molecular Weight Heparin on Proliferation,Cellcycle and Apoptosis of Lung Adenocarcinoma A549 Cell

doi:10.16333/j.10016880.2016.S.009

Abstract

Abstract: To explore the effect of LMWH on proliferation,the cycle and apoptosis of lung adenocarcinoma A549 cell.Respectively by MTT,PI staining,flow cytometry,inverted microscope detection of cell proliferation,cell cycle distribution,morphological changes of apoptosis and cell.The results showed,low molecular weight heparin can inhibit the growth of A549 lung carcinoma cell,cell cycle arrest in G0/G1 phase (P<0.05),apoptosis (P<0.05),the effect of inhibition was time and concentration dependent.

Key words: low molecular weight heparin, lung adenocarcinoma A549 cell, cell proliferation, cell apoptosis

CLC Number:

R914

SONG Dawei1,LI Liangyu2,ZHANG Liping1*. Inhibitory Effect of Low Molecular Weight Heparin on Proliferation,Cellcycle and Apoptosis of Lung Adenocarcinoma A549 Cell[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(Suppl1): 30-34.

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Inhibitory Effect of Low Molecular Weight Heparin on Proliferation,Cellcycle and Apoptosis of Lung Adenocarcinoma A549 Cell

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