Abstract: The anti-inflammatory activity and constituents of total diterpenoids in Rabdosia excisa were evaluated.Anti-inflammatory action of total diterpenoids was carried out by the macrophage RAW264.7 cells and ear edema induced by dimethylbenzene in mice.The chemical constituents of total diterpenoids fraction were identified by liquid chromatography-mass spectrometry (LCMS).The results indicated that total diterpenoids and kamebakaurin (100 μg/mL) could reduce significantly lipopolysaccharide (LPS)-induced macrophage inflammatory cytokine.Compared with control group,the high dose groups significantly reduced the swelling induced by dimethylbenzene in mice.The low dose group had the tendency of inhibition,and ethanol extract (low dose,100 mg/kg) showed the inhibition closing to indomethacin (Indo,25 mg/kg).

Key words: Rabdosia excisa, total diterpenoids, anti-inflammatory activity, LC-MS