NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (6): 941-944. doi: 10.16333/j.1001-6880.2015.06.001

• Article •     Next Articles

Synthesis of Natural Product (+)-Balasubramide

LI Jun,YI Xin-yu,DING Li,LIN Han-sen*   

  1. College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China
  • Online:2015-06-30 Published:2015-07-10

Abstract: In this study,(+)-balasubramide was totally synthesized by selecting cinnamaldehyde as starting material with asymmetric epoxidation via one-pot reaction,amine-ester interchange and intramolecular cyclization.Natural product (+)-balasubramide was synthesized with a 44% overall yield and excellent enantioselectivity (>99%) and confirmed by 1H NMR, 13C NMR,HR-MS and IR.This paper described a convenient and efficient method for the synthesis of natural (+)-balasubramide and laid a certain foundation for the further study of bioactivity and structure-activity relationships of this compound.

Key words: (+)-balasubramide, cinnamaldehyde, asymmetric catalysis, synthesis

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