Abstract: Mogrosides are components of cucurbitane triterpenes,have hypoglycemic activity,and are found in the fruit Siraitia grosvenorii.The mechanism by which mogrosides reduced blood sugar was complex and needed to be interpreted;in addition,there was a problem of low content of mogrosides in Siraitia grosvenii,and biosynthesis was an attractive way to produce mogrosides on a large scale.In terms of biosynthesis of mogrosides,the key enzymes have been cloned and expressed,which provided the basis for mogroside synthesis and the establishment of cell factories.In this paper,the hypoglycemic effect and the progress of the biosynthesis mechanism of mogrosides was reviewed,which provided the reference for advancing the development and biosynthesis of mogrosides.

Key words: Mogrosides, glycemia regulation, triterpene, biosynthesis