Diabetic foot ulcer (DFU) is a common complication of diabetes, which is manifested as foot ulcer combined with infection, has a long treatment cycle, and has a high disability and mortality rate. At present, the therapeutic effect of modern medicine on DFU is not satisfactory, and with the continuous development of traditional Chinese medicine, the multi-target, multi-pathway, multi-level and multi-system therapeutic advantages of traditional Chinese medicine make the effect in the treatment of DFU more and more significant. Modern studies have shown that the occurrence and development of DFU is related to multiple signaling pathways, among which the Wnt/β-catenin signaling pathway is the most closely related to DFU, and is involved in the occurrence and development of DFU by regulating the expression of related signaling proteins and genes. In recent years, studies have found that TCM monomers, extracts and compounds can play a therapeutic role in the treatment of DFU by regulating the expression of proteins and genes downstream of the Wnt/β-catenin pathway. However, there is a lack of systematic collation and induction, based on this, this paper combs the relevant literature at home and abroad, analyzes and explains the mechanism of TCM intervention in the treatment of DFU by Wnt/β-catenin signaling pathway, and summarizes and summarizes the traditional Chinese medicine monomers, extracts and compounds that target the regulation of this signaling pathway, in order to provide reference for the clinical treatment and drug development of DFU.