Abstract: PsL(Pteris Semipinnata L.),is a common used herb in southern China.5F extracted from the PsL has good anti-tumor effect.This paper is to sum up the research progress of anti-tumor effect of 5F,from the aspects of anti-tumor efficacy in vitro and in vivo, apoptosis,cell cycle,NF-κB pathway, p53,ROS,MAPK pathway,tumor invasion and metastasis.

Key words: Pteris semipinnata L., 5F, anti-tumor