天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (3): 328-330.

• 研究论文 • 上一篇    下一篇

深海真菌Penicillium herquei FS83次生代谢产物研究(补充数据)

李浩华,潘清灵,陈玉婵,李赛妮,谭国慧,叶伟,刘洪新,孙章华*,章卫民*   

  1. 广东省微生物研究所 省部共建华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室,广州 510070
  • 出版日期:2016-03-30 发布日期:2016-04-07

Secondary Metabolites from Deep-Sea-Derived Fungus Penicillium herquei FS83

LI Hao-hua,PAN Qin-ling,CHEN Yu-chan,LI Sai-ni,TAN Guo-hui, YE Wei,LIU Hong-xin,SUN Zhang-hua*,ZHANG Wei-min*   

  1. State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key  Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied  Microbiology,Guangdong Institute of Microbiology,Guangzhou 510070,China
  • Online:2016-03-30 Published:2016-04-07

摘要: 利用正相硅胶柱、反相硅胶柱、凝胶柱、薄层层析以及高效液相色谱法等色谱技术从深海真菌Penicillium herquei FS83的液体发酵产物中分离得到5个化合物,通过波谱数据分析结合文献对照,分别鉴定为peniherin A(1)、sclerodin(2)、对羟基苯乙酸甲酯(3)、对羟基苯乙酮(4)、(R)-甲羟戊酸内酯(5)。其中化合物1为新化合物,化合物2为首次从该属真菌中分离得到。生物活性实验显示,化合物1无明显细胞毒活性及抑菌活性。

关键词: Penicillium herquei, 深海真菌, 次生代谢产物, 异香豆素

Abstract: Five compounds were isolated from the extract of the deep-sea-derived fungus Penicillium herquei FS83 by utilizing various chromatographic methods such as silica gel,reverse silica gel,Sephadex LH-20,preparative TLC and HPLC.Their structures were identified as peniherin A (1),sclerodin (2),methyl (4-OH) phenylacetate (3),4-hydroxyacetophenone (4),(R)-mevalonolactone (5),respectively,by spectroscopic data.Compound 1 was identified as a new compound,and compound 2 was isolated from Penicillium for the first time.No cytotoxic and antibacterial activities were detected for compound 1.

Key words: Penicillium herquei, deep-sea-derived fungus;secondary metabolites;isocoumarin

中图分类号:  R284.1