天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (增刊1): 167-170.doi: 10.16333/j.1001-6880.2020.S.027

• 综述 • 上一篇    下一篇

大麻二酚抗癌作用研究进展

郭子琪1，黄桂玲2，王少康1*，孙桂菊1   

  1. 1东南大学公共卫生学院环境医学工程教育部重点实验室 营养与食品卫生学系，南京 210009；2江苏医药职业学院，盐城 224005 

  • 出版日期:2020-06-28 发布日期:2020-07-21
  • 基金资助:
    国家自然基金面上项目（81673147）

Research progress on anticancer effect of cannabidiol

GUO Zi-qi1,HUANG Gui-ling2,WANG Shao-kang1*,SUN Gui-ju1   

  1. 1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009, China;2Jiangsu Vocational College of Medicine,Yancheng 224005,China

  • Online:2020-06-28 Published:2020-07-21

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摘要：

大麻具有重要的药用价值，是因为从大麻中可分离出的大麻素。目前研究发现大麻素有113种，其中四氢大麻酚和大麻二酚的含量最高。四氢大麻酚是大麻中的精神活性成分，具有严重的副作用即致幻和成瘾作用，而大麻二酚是大麻中的非精神活性成分，可阻碍四氢大麻酚对神经系统的影响，且没有致幻和成瘾作用。本文全面阐述了大麻二酚的抗癌作用，包括抗白血病、抗神经胶质瘤、抗乳腺癌、抗前列腺癌、抗肺癌、抗结直肠癌的作用及其机制。旨在为大麻二酚治疗各种癌症提供科学参考。

关键词: 大麻二酚, 白血病, 神经胶质瘤, 乳腺癌, 前列腺癌, 肺癌, 结直肠癌

Abstract:

Cannabis has important medicinal value because of the cannabinoids that can be separated from cannabis.At present,113 types of cannabinoids have been found in the study,among which the content of tetrahydrocannabinol and cannabidiol is the highest.Tetrahydrocannabinol is a psychoactive component in cannabis with serious side effects,namely hallucinogenic and addictive effects,while cannabidiol is a non-psychoactive component in cannabis,which can hinder the effects of tetrahydrocannabinol on the nervous system,and no hallucinogenic and addictive effects.This article comprehensively describes the anticancer effects of cannabidiol,including anti-leukemia,anti-glioma,anti-breast cancer,anti-prostate cancer,anti-lung cancer,anti-colorectal cancer and their mechanisms.It aims to provide scientific reference for the treatment of various cancers by cannabidiol.

Key words: cannabidiol, leukemia, glioma, breast cancer, prostate cancer, lung cancer, colorectal cancer

中图分类号:  R285

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