山楝枝叶中两个新的倍半萜(补充数据）

天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (2): 223-226.

山楝枝叶中两个新的倍半萜(补充数据）

秦天丽, 陈彦伍, 吴石丽, 张凡, 李明明, 何红平

1云南中医药大学中药学院；2云南中医药大学民族医药学院，昆明 650500

出版日期:2021-02-28 发布日期:2021-03-03

Two new sesquiterpene from stems and leaves of Aphanamixis polystachya

QIN Tian-li, CHEN Yan-wu, WU Shi-li, ZHANG Fan, LI Ming-ming, HE Hong-ping

1College of Traditional Chinese Medicine，Yunnan University of Chinese Medicine；2College of Chinese National Medicine，Yunnan University of Chinese Medicine，Kunming 650500，China

Online:2021-02-28 Published:2021-03-03

摘要/Abstract

摘要： 本文报道了对山楝Aphanamixis polystachya枝叶的化学成分进行研究。采用硅胶柱色谱、Sephadex LH-20、RP-C₁₈、HPLC等色谱分离手段，从其95%乙醇提取物中分离得到9个化合物，通过波谱方法进行鉴定为polystachyadione A（1）、polystachyadione B（2）、labd-13(E）-ene-8α，15-diol（3）、labd-13(E）-ene-8α，15-yl acetate（4）、1S，4S，5S，10R-4，10-愈创木二醇（5）、齐墩果酸（6）、3，4-二羟基苯甲酸（7）、反式咖啡酸（8）和单棕榈酸甘油酯（9）。其中化合物1和2为两个新化合物，化合物4、7、8和9为首次从该植物中分离得到。化合物1、2对脂多糖诱导的RAW 264.7细胞NO生成没有表现出明显的抑制作用。

Abstract:

To investigate the chemical constituents of the branches and leaves of Aphanamixis polystachya.Nine compounds were isolated from the 95% ethanol extract of A. polystachya by various column chromatography involving silica gel,Sephadex LH-20 gel,RP-C₁₈and HPLC.Their structures were identified by chemical properties and spectroscopic analyses，and were elucidated as polystachyadione A (1),polystachyadione B (2),labd-13(E)-ene-8α,15-diol (3),labd-13(E)-ene-8α,15-yl acetate(4),1S,4S,5S,10R-4,10-guaianediol (5),oleanolic acid (6),3,4-dihydroxybenzoic acid (7),caffeic acid (8) and α-monopalmitin (9),of which compounds 1 and 2 are new.Compounds 4,7,8 and 9 are obtained from this plant for the first time.The activity tests showed that compounds 1 and 2 have no significant inhibition against NO production.

秦天丽, 陈彦伍, 吴石丽, 张凡, 李明明, 何红平. 山楝枝叶中两个新的倍半萜(补充数据）[J]. 天然产物研究与开发, 2021, 33(2): 223-226.

QIN Tian-li, CHEN Yan-wu, WU Shi-li, ZHANG Fan, LI Ming-ming, HE Hong-ping(Supplementary data）. Two new sesquiterpene from stems and leaves of Aphanamixis polystachya[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(2): 223-226.