The aim of this study is to investigate the effects of Citri Reticulatae Pericarpium (CP),Angelicae Dahuricae Radix (AR),Descurainiae Semen (DS) and Belamcandae Rhizoma (BR) on energy metabolism in mice model with lung heat syndrome and its mechanism.The mouse model with lung heat syndrome was established and treated with CP,AR,DS and BR.The morphological changes of lung were observed by hematoxylin-eosin staining method,and the contents of adrenocorticotropin (ACTH) and dopamine-β hydroxylase (DBH) in serum were detected by enzyme-linked immunosorbent assay method.The levels of Na⁺-K⁺-ATPase,succinate dehydrogenase (SDH),lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in mouse liver tissue were detected by biochemical kit.The protein and mRNA expression levels of adenylate activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) in liver tissue were detected by immunohistochemistry and real-time quantitative polymerasechain reaction.The results showed that compared with the model group,CP,AR,DS and BR reduced the expression levels of ACTH,DBH in serum and Na⁺-K⁺-ATPase,SDH,SOD in liver tissue,as well as the expression levels of AMPK,PGC-1α protein and mRNA in liver tissue,and enhanced the expression level of LDH.CP,AR,DS and BR may regulate the energy metabolism of lung heat syndrome model mice by inhibiting the AMPK/PGC-1α signaling pathway.