关键词: 细胞凋亡, Fas/FasL, 黄酮, 生物碱, 新药研发

Abstract: Natural medicine becomes the research hotspot of antitumor drugs for the characteristics of extensive effects,good curative effects and small toxic and side effects,and modernists’ psychology of returning to nature.In the early time,most of the research of which on chemical or natural products by chemists or natural medicine researchers were limited to the normal pharmacological activity screening.With the advance of science and technology,there is development crossed and permeated among different subjects,and research on the antitumor action mechanism of natural antitumor drugs and natural activity antitumor effect can be further explored constantly,the action target spot and pathways on a lot of antitumor drugs or activity chemical compositions can be elaborated.Besides,Fas and Ligand FasL are membrane molecules related to cell apoptosis which are studied very intensively in recent years.It’s found through a lot of studies that a number of natural medicines can strengthen Fas expression of tumor cells and start Fas/Fasl pathways so as to have the effect of inducing tumor cell apoptosis.Flavone and alkaloids are chemical compounds are extensively distributed,studied deeply and have significant biological activity in natural products.In order to further study these two chemical compounds,natural flavone and alkaloids are used to induce tumor cell apoptosis through Fas/FasL pathway as the literature review,the purpose of which is to offer reference for the further study on the antitumor activity and mechanisms of these two compositions.

Key words: cell apoptosis, Fas/FasL, flavones, alkaloid, drug discovery