NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2021, Vol. 33 ›› Issue (1): 150-164.doi: 10.16333/j.1001-6880.2021.1.018

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Advance on natural products and their pharmacological activities and biosynthesis from Beauveria species

XIE Li-yuan1,YIN Wen-Bing2,LI Wei 2,3*,GAO Wei1*   

  1. 1Capital Medical University,School of Chinese Medicine,Beijing 100069,China; 2Institute of Microbiology Chinese Academy of Sciences,State Key Laboratory of Mycology,Beijing 100101,China;3Henan Academy of Science Institute of Biology Co.,Ltd.,Zhengzhou 450008,China
  • Online:2021-01-28 Published:2021-01-28

Abstract:

Beauveria species are important entomopathogenic fungi producing a large variety of natural products including peptides,polyketides,alkaloids,phenylpropanoids,terpenes and nucleosides.These compounds show various bioactivities such as anti-tumor,insecticidal activity,antibacterial action and antiviral activity.Moreover,the biosynthesis pathways of some active molecules including beauvericin,beauveriolide,bassianolide,oosporein and tenellin have been explored based on the development of genome sequencing technology and genetic manipulation.All of which provide a good foundation for discovery of unknown structures by genome mining and application of known active molecules in Beauveria species.In this review,the chemical constituents,bioactivities and the biosynthesis pathways of natural products produced in Beauveria spp. were summarized,and all of which provided the reasons for exploiting systematacially the natural product resourses in Beauveria species.

Key words: Beauveria, natural products, bioactivity, gene cluster, biosynthesis

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