NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (3): 433-437.doi: 10.16333/j.1001-6880.2016.3.021

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Antagonistic Effect of Fucoidan from Laminaria japonica Against Adenine-Induced Hyperuricemia in Mice

ZHANG Da-yan1,XIAO Wei1 ,TAO Ye-xing2,GU Yi-peng3,LIU Hua-zhong4*   

  1. 1 College of Food Science & Technology,Guangdong Ocean University,Zhanjiang 524088,China; 2 Science Experiment Center,Guilin Medical University,Guilin 541004,China; 3 Guangxi Buffalo Research Institute,Chinese Academy of Agricultural Sciences,Nanning 53001,China;  4 College of science,Guangdong Ocean University,Zhanjiang 524088,China
  • Online:2016-03-30 Published:2016-04-07

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Abstract: The antagonistic effect of fucoidan from Laminaria japonica (FL) on hyperuricemia in mice induced by adenine was studied.The hyperuricemia mice model was established by oral gavage of adenine,and then cured by different doses of FL (0.100,0.150,0.200 g/kg) for 4 weeks.The level of mice serum uric acid,creatinine,the activity of homogenate of adenosine deaminase (ADA) and xanthine oxidase (XOD) in liver,and HE staining of kidney were measured.Results showed that,mice exposed to the adenine presented significantly higher level of uric acid,creatinine,activities of ADA and XOD (P<0.01) than these of normal mice,but mice exposed to the different doses of FL significantly reduced the level of uric acid,creatinine,activities of ADA and XOD (P<0.01) when compared to model group.In addition,the kidney histopathology was observed to restore to normal conditions in FL treatment mice.In conclusion,FL exhibited an obviously positive effect on hyperuricemia mice.

Key words: fucoidan, hyperuricemia, purine metabolism

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