NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (10): 1663-1668.doi: 10.16333/j.1001-6880.2018.10.001

• Article •     Next Articles

Phenazine Alkaloid Secondary Metabolites from Actinomycete Streptomyces nojiriensis SCSIO m34-1

LI Yu1,2#,LAI Zhen-zhu3#,LI Jia-ling4,HUANG Hong-bo1,XIE Yun-chang1,LI Wen-jun4,TAO Yi-wen3,JU Jian-hua1,2*   

  1. 1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China; 2University of Chinese Academy of Sciences,Beijing,100049,China; 3School of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou 511436,China; 4School of Life Sciences,Sun Yat-sen University,Guangzhou,510275
  • Online:2018-10-31 Published:2018-11-01

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Abstract: An actinomycetes strain SCSIO m34-1 was isolated from soil sample collected from Mohe,Heilongjiang province,China.The strain was identified as Streptomyces nojiriensis SCSIO m34-1 by analysis of its 16S rRNA gene sequence.The strain SCSIO m34-1 was fermented on rotary shakers.Seven compounds were purified from the organic extract using silica gel column chromatography and semi-preparative HPLC.Their structures were identified to be izuminoside D (1),izuminoside A (2),solphenazine E (3),solphenazine D (4),solphenazine A (5),methyl 6-hydroxy phenazine-1-carboxylate (6) and diastaphenazine (7) based on analyses of their HR-MS,1D and 2D NMR data.Izuminoside D (1) was found to be a new compound.Izuminoside D (1) showed weak antifungal activity against Valsa mali and Gibberella sanbinetti at the concentration of 50 μg/mL.

Key words: Streptomyces, secondary metabolite, alkloaid, phenazine

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