New Polyketide Isolated from Aspergillus fumigatus, A Cordyceps-colonizing Fungus

doi:10.16333/j.1001-6880.2018.4.009

Abstract

Abstract: Aspergillus fumigatus,a Cordyceps-colonizing fungus has been isolated from Cordyceps sinensis and its chemical constituents were investigated.A new compound 1 had been isolated from EtOAc extract of the fermentation broth by silica gel,RP C₁₈column chromatography and preparative HPLC and its structure was elucidated as 6-methoxy-3-methyl-1H-isochromen-8-ol by various spectroscopic data (HR-ESI-MS,1D NMR,2D NMR).Compound 1 was shown to have weak cytotoxic activity against the H1299,H460,HGC-27,A549 and mnk-43.

Key words: Aspergillus fumigatus, Cordyceps sinensis, 6-methoxy-3-methyl-1H-isochromen-8-ol, structural elucidation, cytotoxic activity

CLC Number:

R284.1

LI Sha, LI Xiao-hua, QIU Ling, KUANG Qi-xuan, WEN Xin, YU Si, GUO Da-le*, DENG Yun*. New Polyketide Isolated from Aspergillus fumigatus, A Cordyceps-colonizing Fungus[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2018, 30(4): 588-590.

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New Polyketide Isolated from Aspergillus fumigatus, A Cordyceps-colonizing Fungus

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